Mythology may NOT be Just A Myth: Theoretical Biology may NOT be Just A Theory: Connecting The Dots: Was "Sanjeevani" Naloxone?

نویسندگان

  • Deepak Gupta
  • Pandu Ranga
  • Rao Bangaru
  • Vinay Pallekonda
چکیده

Steve Jobs, the co-founder of Apple Inc., once spoke that the connection among the past-dots happens in the present times, that explore the past in the retrospect. Henceforth, in the below-mentioned and elaborated text, the focus is on the possibility to explore the science underplayed when "Sanjeevani" (the reviver) was documented in the Hindu mythological epic, titled Ramayan written by sage Valmiki. It is our presumptive analysis that the sub-plot woven around "Sanjeevani" might have been to postulate the theoretical biology surrounding the catastrophic inhalational or infiltrating routes of opioids against the enemies in the ancient times and the corresponding use of inhalational or intranasal routes of antidotes to revive the victims. Who knows this was setting the grounds for future use of opioids (≈ Sammohini) under controlled conditions to induce analgesia-anesthesia and subsequent reversal of analgesia-anesthesia by naloxone (≈ Sanjeevani). Although, in recent texts, Rhodiola and Selaginella species have been suggested to come the closest to the claim as being the mythological Sanjeevani, it is our alternative postulation and interpretation that naloxone can be the elusive-enigmatic Sanjeevani as a derived component of thebaine, the extractable alkaloid of Papaver bracteatum.

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تاریخ انتشار 2016